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Phenotypes Associated with This Genotype
Genotype
MGI:3765897
Allelic
Composition		 Ifnar1tm1Agt/Ifnar1tm1Agt
Tg(Hmgcr-MX1)LStae/Tg(Hmgcr-MX1)LStae
Genetic
Background		 involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifnar1tm1Agt mutation (12 available); any Ifnar1 mutation (61 available)
Tg(Hmgcr-MX1)LStae mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:119783 )
• mice infected with Thogoto virus all survive while littermate controls die within 5 days
• only 43% of mice die from La Crosse virus infection as opposed to Ifnar1tm1Agt mice in which 94% die
• only 59% of mice die from Semliki Forest virus infection as opposed to 100% of Ifnar1tm1Agt mice

immune system
decreased susceptibility to Orthomyxoviridae infection ( J:119783 )
• no Thogoto virus is detectable in liver 36 hours after infection
decreased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:119783 )
• mice infected with Thogoto virus all survive while littermate controls die within 5 days
• only 43% of mice die from La Crosse virus infection as opposed to Ifnar1tm1Agt mice in which 94% die
• only 59% of mice die from Semliki Forest virus infection as opposed to 100% of Ifnar1tm1Agt mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory