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Phenotypes Associated with This Genotype
Genotype
MGI:3765456
Allelic
Composition		 Cd1d1tm1Luc/Cd1d1tm1Luc
Genetic
Background		 B6.129S6-Cd1d1tm1Luc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd1d1tm1Luc mutation (2 available); any Cd1d1 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased regulatory T cell number ( J:122245 )
• unlike in wild-type mice, treatment with alpha-GalCer fails to elicit an expansion of regulatory T cells following induction of experimental autoimmune myasthenia gravis
autoimmune response ( J:122245 )
• unlike in wild-type mice, treatment with alpha-GalCer fails to protect mice from experimental autoimmune myasthenia gravis

hematopoietic system
decreased regulatory T cell number ( J:122245 )
• unlike in wild-type mice, treatment with alpha-GalCer fails to elicit an expansion of regulatory T cells following induction of experimental autoimmune myasthenia gravis

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory