Phenotypes Associated with This Genotype

Genotype
MGI:3765443

• Allelic Composition: Mx1^s1/Mx1^s1; Tg(Hmgcr-MX1)LStae/?
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to Riboviria infection induced morbidity/mortality ( J:128067 )

• decreased lethality is observed in mice challenged with influenza A virus or VSV

• mice infected with VSV by an intracerebal route have longer mean survival times (2.7 days vs. 1.5)

decreased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:128067 )

• no lethality is observed in mice challenged with Thogoto virus while all the littermate controls died

• mice infected with influenza A virus by an intracerebal route have longer mean survival times (6.0 days vs. 3.9)

• mice infected with pneumotropic influenza A virus have increased rates of survival (33.3% vs 0%) for wild-type controls

immune system

decreased susceptibility to Riboviria infection ( J:128067 )

• supernatant of embryonic fibroblasts infected with VSV contains 10-40 fold less infectious particles 25 hours after infection

decreased susceptibility to Riboviria infection induced morbidity/mortality ( J:128067 )

• decreased lethality is observed in mice challenged with influenza A virus or VSV

• mice infected with VSV by an intracerebal route have longer mean survival times (2.7 days vs. 1.5)

decreased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:128067 )

• no lethality is observed in mice challenged with Thogoto virus while all the littermate controls died

• mice infected with influenza A virus by an intracerebal route have longer mean survival times (6.0 days vs. 3.9)

• mice infected with pneumotropic influenza A virus have increased rates of survival (33.3% vs 0%) for wild-type controls

decreased susceptibility to Orthomyxoviridae infection ( J:128067 )

• supernatant of embryonic fibroblasts infected with influenza A virus contains 10-40 fold less infectious particles 25 hours after infection

• supernatant of embryonic fibroblasts infected with Thogoto virus contains no infectious particles 3 days after infection