Phenotypes Associated with This Genotype

Genotype
MGI:3765069

• Allelic Composition: Ighmbp2^nmd-2J/Ighmbp2^nmd-2J; Tg(Eno2-Ighmbp2)17Cx/?
• Genetic Background: involves: C57BL/6J * C57BLKS/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:90418 )

• at 49 days for males and 54 days for females

• maximum life span is 87 days for females

cardiovascular system

abnormal cardiovascular system physiology ( J:90418 )

dilated cardiomyopathy ( J:90418 )

• grossly dilated hearts with one or more thrombi

abnormal impulse conducting system conduction ( J:90418 )

prolonged PR interval ( J:90418 )

• prolonged P-R interval

prolonged P wave ( J:90418 )

• sometimes split

prolonged QRS complex duration ( J:90418 )

• prolonged

muscle

muscle phenotype ( J:90418 )

N • grossly normal hind limb muscle phenotype

dilated cardiomyopathy ( J:90418 )

• grossly dilated hearts with one or more thrombi

muscle degeneration ( J:90418 )

• mild myopathic changes including myocyte degeneration and regeneration with centralized nucleii

nervous system

nervous system phenotype ( J:90418 )

N • axon morphology and nerve root diameters are normal

respiratory system

pulmonary edema ( J:90418 )

• consolidation of lungs

pleural effusion ( J:90418 )

decreased pulmonary respiratory rate ( J:90418 )

• reduced breathing rate (bradypnea)

growth/size/body

weight loss ( J:90418 )

homeostasis/metabolism

increased circulating creatine kinase level ( J:90418 )

• 3-7 days prior to clearly evident clinical signs of heart disease, total plasma CK and cardiac-specific CK-MB levels in 5- to 9-week-old mice become significantly elevated

pulmonary edema ( J:90418 )

• consolidation of lungs

pleural effusion ( J:90418 )