Phenotypes Associated with This Genotype

Genotype
MGI:3765063

• Allelic Composition: Myt1^tm1Ggu/Myt1^tm1.1Ggu; Tg(Pdx1-cre)89.1Dam/?
• Genetic Background: involves: 129 * C57BL/6 * CBA * CD-1 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased insulin secretion ( J:127471 )

• islet cells isolated from 12 week old males secrete a third less insulin in response to high glucose as compared to wild-type controls

impaired glucose tolerance ( J:127471 )

• 30 minutes after glucose injection, mice only had a 30% rise in insulin compared to a 100% rise in wild-type mice

endocrine/exocrine glands

abnormal pancreas development ( J:127471 )

• Mafb production in cells producing more than one hormone suggests delayed maturity of the secretory cells of the pancreas

abnormal PP cell physiology ( J:127471 )

• 10% of pancreatic polypeptide producing cells also express somatostatin which represents a 5 fold increase compared to wild-type controls

• 4.1% of pancreatic polypeptide producing cells also express insulin which represents a 20 fold increase compared to wild-type controls

abnormal pancreatic alpha cell physiology ( J:127471 )

• 2.7% of glucogon producing cells also produce insulin representing a 10 fold increase over wild-type controls

abnormal pancreas secretion ( J:127471 )

decreased insulin secretion ( J:127471 )

• islet cells isolated from 12 week old males secrete a third less insulin in response to high glucose as compared to wild-type controls

abnormal pancreatic somatostatin secretion ( J:127471 )