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Phenotypes Associated with This Genotype
Genotype
MGI:3764985
Allelic
Composition
Mc2rtm1Dchi/Mc2rtm1Dchi
Genetic
Background
B6.129P2-Mc2rtm1Dchi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc2rtm1Dchi mutation (1 available); any Mc2r mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Histological analysis of the adrenal gland of Mc2rtm1Dchi/Mc2rtm1Dchi mice

mortality/aging
• three-quarters of mice die prior to weaning with most dying within the first 48 hours after birth likely due to hypoglycemia with decreased gluconeogenesis in the liver and defective neonatal nutritional adaptatio (J:127445)
• while most mice that display reduced glucose levels die by day 7 mice that maintained normal glucose levels survive (J:127445)
• three-quarters of mice die prior to weaning with most dying within the first 48 hours after birth likely due to hypoglycemia with decreased gluconeogenesis in the liver and defective neonatal nutritional adaptatio (J:127445)
• while most mice that display reduced glucose levels die by day 7 mice that maintained normal glucose levels survive (J:127445)

homeostasis/metabolism
• 0.12+/-0.02 ng/ml compared to 0.72+/-0.14 ng/ml in heterozygotes and 0.59+/-0.08 ng/ml in wild-type mice (J:127445)
• however, norephrinepherine and dopamine levels are normal (J:127445)
• 0.12+/-0.02 ng/ml compared to 0.72+/-0.14 ng/ml in heterozygotes and 0.59+/-0.08 ng/ml in wild-type mice (J:127445)
• however, norephrinepherine and dopamine levels are normal (J:127445)
• corticosterone serum levels are undetectable in male mice (J:127445)
• fasting mice do not display increased corticosterone levels as wild-type mice do (J:127445)
• corticosterone serum levels are undetectable in male mice (J:127445)
• fasting mice do not display increased corticosterone levels as wild-type mice do (J:127445)
• 104+/-25 pg/ml compared to 343+/-103 pg/ml in wild-type mice (J:127445)
• 104+/-25 pg/ml compared to 343+/-103 pg/ml in wild-type mice (J:127445)
• 1394+/-89 pg/ml compared to 370+/-50 pg/ml in heterozygotes and 281+/-106 pg/ml in wild-type mice (J:127445)
• response to adrenocorticotropin is defective (J:127445)
• 1394+/-89 pg/ml compared to 370+/-50 pg/ml in heterozygotes and 281+/-106 pg/ml in wild-type mice (J:127445)
• response to adrenocorticotropin is defective (J:127445)
• in female mice (J:127445)
• in female mice (J:127445)
• blood glucose levels decline faster after a 36-hour fast compared to in wild-type mice (45.8+/-11.7 mg/dl compared to 79.2+/-9.5 mg/dl in wild-type mice) (J:127445)
• blood glucose levels decline faster after a 36-hour fast compared to in wild-type mice (45.8+/-11.7 mg/dl compared to 79.2+/-9.5 mg/dl in wild-type mice) (J:127445)
• at P0.5, 13 of 14 mice are hypoglycemic and 12 of 14 mice had glucose levels below 20 mg/dl (J:127445)
• however, while most mice that display reduced glucose levels die by day 7 mice maintained normal glucose levels survive (J:127445)
• at P0.5, 13 of 14 mice are hypoglycemic and 12 of 14 mice had glucose levels below 20 mg/dl (J:127445)
• however, while most mice that display reduced glucose levels die by day 7 mice maintained normal glucose levels survive (J:127445)
• gluconeogenesis is impaired (J:127445)
• gluconeogenesis is impaired (J:127445)
• in male mice (J:127445)
• in male mice (J:127445)

endocrine/exocrine glands
• in adulthood, zona fasciculata cells exhibit an increase number of lipid droplets and inactive mitochondrial compared to wild-type mice (J:127445)
• however, zona glomerulosa cells are normal and adrenal glands of newborn mice are normal (J:127445)
• in adulthood, zona fasciculata cells exhibit an increase number of lipid droplets and inactive mitochondrial compared to wild-type mice (J:127445)
• however, zona glomerulosa cells are normal and adrenal glands of newborn mice are normal (J:127445)
• in adulthood, the thickness of the adrenal capsule is increased compared to in wild-type mice (J:127445)
• in adulthood, the thickness of the adrenal capsule is increased compared to in wild-type mice (J:127445)
• 0.58+/-0.02 mg per pair compared to 2.24+/-0.18 mg per pair in wild-type mice (J:127445)
• while cell number is not reduced cell size is compared to in wild-type adrenal glands (J:127445)
• 0.58+/-0.02 mg per pair compared to 2.24+/-0.18 mg per pair in wild-type mice (J:127445)
• while cell number is not reduced cell size is compared to in wild-type adrenal glands (J:127445)

behavior/neurological
• some mice are pale and lethargic at birth (J:127445)
• some mice are pale and lethargic at birth (J:127445)

adipose tissue

cardiovascular system
• heart rate is decreased (J:127445)
• however, blood pressure is normal (J:127445)
• heart rate is decreased (J:127445)
• however, blood pressure is normal (J:127445)

hematopoietic system

immune system

growth/size/body

Mouse Models of Human Disease
OMIM ID Ref(s)
Glucocorticoid Deficiency 1; GCCD1 202200 J:127445


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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory