Phenotypes Associated with This Genotype

Genotype
MGI:3764888

• Allelic Composition: Trpc1^tm1Lbi/Trpc1^tm1Lbi
• Genetic Background: involves: 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal submandibular gland physiology ( J:127118 )

• carbachol or thapsigarin stimulated Ca²⁺ entry into submandibular gland acinar cells is reduced by over 60% compared to wild-type control cells

• both inward and outward store-operated cation currents are severely reduced in submandibular gland acinar cells

decreased salivation ( J:127118 )

• saliva secretion and flow are severely reduced after parasympathetic stimulation with pilocarpine

• however, submandibular gland morphology and size are similar to wild-type controls

endocrine/exocrine glands

abnormal submandibular gland physiology ( J:127118 )

• carbachol or thapsigarin stimulated Ca²⁺ entry into submandibular gland acinar cells is reduced by over 60% compared to wild-type control cells

• both inward and outward store-operated cation currents are severely reduced in submandibular gland acinar cells

decreased salivation ( J:127118 )

• saliva secretion and flow are severely reduced after parasympathetic stimulation with pilocarpine

• however, submandibular gland morphology and size are similar to wild-type controls

nervous system

nervous system phenotype ( J:139695 )

N • normal slow EPSC

N • normal mGluR1 (Grm1) mediated synaptic transmission

homeostasis/metabolism

decreased salivation ( J:127118 )

• saliva secretion and flow are severely reduced after parasympathetic stimulation with pilocarpine

• however, submandibular gland morphology and size are similar to wild-type controls