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Phenotypes Associated with This Genotype
Genotype
MGI:3764846
Allelic
Composition		 Ccm2Gt(RRG051)Byg/Ccm2+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccm2Gt(RRG051)Byg mutation (0 available); any Ccm2 mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Vascular malformations in the brains of Ccm2Gt(RRG051)Byg/Ccm2+ mice

cardiovascular system
abnormal brain vasculature morphology ( J:105314 )
• develop cerebral vascular malformations, including hemorrhaging, at low penetrance; clusters of blood vessels are similar to small cavernous malformations or capillary telangiectasias
intracranial hemorrhage ( J:105314 )
• low penetrance

nervous system
abnormal brain vasculature morphology ( J:105314 )
• develop cerebral vascular malformations, including hemorrhaging, at low penetrance; clusters of blood vessels are similar to small cavernous malformations or capillary telangiectasias
intracranial hemorrhage ( J:105314 )
• low penetrance

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory