Phenotypes Associated with This Genotype

Genotype
MGI:3764686

• Allelic Composition: Ptpn4^tm1Tya/Ptpn4^tm1Tya
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal eye blink conditioning behavior ( J:127245 )

• mice exhibit impaired memory formation in the cerebellum-dependent delay eye blink conditioning

• using a 450-ms tone conditioned stimulus and a 100-ms periorbital electric shock unconditioned stimulus, mice are slower to acquire conditioned response compared to wild-type mice

• electromyogram amplitude is lower on day 3 but not day 7 compared to wild-type mice

• however, unconditioned response electromyogram amplitude is the same as in wild-type mice

impaired coordination ( J:127245 )

• mice exhibit impaired coordination on an accelerated rotarod

• however, coordination on a fixed-bar and narrow bar is normal

nervous system

nervous system phenotype ( J:127245 )

N • mice exhibit normal cerebellar development, sensory perception and response, and excitatory synaptic transmissions in Purkinje cells

reduced long-term depression ( J:127245 )

• mice exhibit impaired cerebellar long term depression (76.8+/-2.4% compared to 61.9+/-2.1% in wild-type mice 21 to 30 minutes after conditioning)