Phenotypes Associated with This Genotype

Genotype
MGI:3764675

• Allelic Composition: Tg(Myh6-tTA)55Rbns/?; Tg(Myh6/tetO-BNIP3)1Gwd/?
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased heart weight ( J:127533 )

• when expression begins neonatally, heart weight is increased (8.7+/-0.9 mg/g compared to 5.7+/-0.3 mg/g in wild-type mice)

dilated heart left ventricle ( J:127533 )

• whether expression begins neonatally or at 8 weeks of age, neonates develop progressive left ventricle dilation that is not as severe in adulthood

decreased left ventricle systolic pressure ( J:127533 )

• whether expression begins neonatally or at 8 weeks of age, left ventricle systolic pressure is decreased compared to in wild-type mice

increased myocardial infarct size ( J:127533 )

• whether expression begins neonatally or at 8 weeks of age, infarct size is larger than in wild-type mice

muscle

increased cardiomyocyte apoptosis ( J:127533 )

• whether expression begins neonatally or at 8 weeks of age, apoptotic rate in the heart is increased 5- to 10-fold at 10 or 40 weeks of age

homeostasis/metabolism

increased myocardial infarct size ( J:127533 )

• whether expression begins neonatally or at 8 weeks of age, infarct size is larger than in wild-type mice

cellular

increased cardiomyocyte apoptosis ( J:127533 )

• whether expression begins neonatally or at 8 weeks of age, apoptotic rate in the heart is increased 5- to 10-fold at 10 or 40 weeks of age

growth/size/body

increased heart weight ( J:127533 )

• when expression begins neonatally, heart weight is increased (8.7+/-0.9 mg/g compared to 5.7+/-0.3 mg/g in wild-type mice)