Phenotypes Associated with This Genotype

Genotype
MGI:3764512

• Allelic Composition: Mt1^tm1Bri/Mt1^tm1Bri; Mt2^tm1Bri/Mt2^tm1Bri
• Genetic Background: 129S7/SvEvBrd-Mt1^tm1Bri Mt2^tm1Bri

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:16487 )

• death occurs between 2-4 days after administration of cadmium, no deaths are observed in control mice

• males die earlier and more often than females after cadmium injection

liver/biliary system

abnormal liver morphology ( J:16487 )

• 4 days after administration of cadmium, livers exhibit focal areas of cellular degeneration, necrosis, congestion and hemorrhaging

hepatic necrosis ( J:16487 )

• necrosis observed following administration of cadmium

liver degeneration ( J:16487 )

• degeneration observed following administration of cadmium

homeostasis/metabolism

abnormal circulating enzyme level ( J:16487 )

• untreated females have 2-fold higher levels of serum glutamic-pyruvic transaminase (SGPT) and serum glutamic-oxaloacetic transaminase (SGOT) than untreated controls

• following 2 days of cadmium treatment, males exhibit a significant increase in SGOT and SGPT levels over treated control males

increased circulating alkaline phosphatase level ( J:16487 )

• increased levels observed in untreated males and females as compared to controls