Phenotypes Associated with This Genotype

Genotype
MGI:3764505

• Allelic Composition: Camk2a^tm1Sva/Camk2a^tm1Sva
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal CNS synaptic transmission ( J:113007 )

• short term potentiation is absent

• however, post-tetanic potentiation is normal

reduced long-term potentiation ( J:113007 )

• mice exhibit little to no long term potentiation after a priming period of low-frequency stimulation unlike in wild-type mice

reduced long-term depression ( J:113007 )

• long term depression is present but reduced compared to in wild-type mice