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Phenotypes Associated with This Genotype
Genotype
MGI:3763821
Allelic
Composition
Adamts13tm1Myta/Adamts13tm1Myta
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts13tm1Myta mutation (0 available); any Adamts13 mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• there are about 2-fold more platelet counts in the serum 15 minutes after challenge with collagen and epinephrine

homeostasis/metabolism
• 29% increase in von Willebrand factor antigen in blood
• 46% increase in FVIII activity in the blood
• there are about 2-fold more platelet counts in the serum 15 minutes after challenge with collagen and epinephrine
• thrombus volume is increased when blood is perfused for 5 minutes over a collagen coated surface

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Thrombotic Thrombocytopenic Purpura, Congenital; TTP 274150 J:125786


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory