Phenotypes Associated with This Genotype

Genotype
MGI:3763713

• Allelic Composition: Tg(Pgk1-FGF2)15Cofn/?
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal response to cardiac infarction ( J:126804 )

• scar thickness 4 weeks post-infarct induction is greater than in wild-type mice (0.64+/-0.07 mm compared to 0.30+/-0.04 mm in wild-type mice)

• however, infarct size and scar contraction are the same as in wild-type mice

• following infarct induction, mice exhibit increased cardiomyocyte hypertrophy (47% increase in cross-section area compared to 19% increase in cross-section area in wild-type mice)

• fibroblast proliferation at 2 days, 4 days and 1 week post-infarct induction is increased more than twice compared to in wild-type mice while total duration of proliferation is shorter than in wild-type mice

• interstitial fibrosis is exaggerated compared to in wild-type mice following infarct induction (81% compared to 58% in similarly treated wild-type mice)

homeostasis/metabolism

abnormal response to cardiac infarction ( J:126804 )

• scar thickness 4 weeks post-infarct induction is greater than in wild-type mice (0.64+/-0.07 mm compared to 0.30+/-0.04 mm in wild-type mice)

• however, infarct size and scar contraction are the same as in wild-type mice

• following infarct induction, mice exhibit increased cardiomyocyte hypertrophy (47% increase in cross-section area compared to 19% increase in cross-section area in wild-type mice)

• fibroblast proliferation at 2 days, 4 days and 1 week post-infarct induction is increased more than twice compared to in wild-type mice while total duration of proliferation is shorter than in wild-type mice

• interstitial fibrosis is exaggerated compared to in wild-type mice following infarct induction (81% compared to 58% in similarly treated wild-type mice)