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Phenotypes Associated with This Genotype
Genotype
MGI:3763640
Allelic
Composition		 Fgf2tm1Doe/Fgf2tm1Doe
Genetic
Background		 B6.129P2-Fgf2tm1Doe
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf2tm1Doe mutation (1 available); any Fgf2 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal vascular endothelial cell migration ( J:114567 )
• following de-endothelialization and treatment with 17beta-Estradiol (E2), mice fail to re-endothelialize the site of injury unlike wild-type mice
• endothelial precursor cell migration in response to E2 is disrupted

cellular
abnormal vascular endothelial cell migration ( J:114567 )
• following de-endothelialization and treatment with 17beta-Estradiol (E2), mice fail to re-endothelialize the site of injury unlike wild-type mice
• endothelial precursor cell migration in response to E2 is disrupted

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory