Phenotypes Associated with This Genotype

Genotype
MGI:3763615

• Allelic Composition: Adm^tm1Unc/Adm⁺; Tg(Alb1-Ren)2Unc/?
• Genetic Background: 129S6/SvEvTac-Adm^tm1Unc Tg(Alb1-Ren)2Unc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased myocardial fiber size ( J:125933 )

• male cardiomyocytes are larger than in Tg(Alb1-Ren)1Unc male mice

• however, there is no difference in cardiomyocyte size in female mice compared to Tg(Alb1-Ren)1Unc female mice

cardiac hypertrophy ( J:125933 )

• male mice exhibit increased cardiac hypertrophy compared to Tg(Alb1-Ren)1Unc male mice

• however, female mice are not significantly different in terms of cardiac hypertrophy compared to female mice containing Tg(Alb1-Ren)1Unc and the degree of coronary artery fibrosis is the same as in Tg(Alb1-Ren)1Unc mice regardless of gender

increased systemic arterial blood pressure ( J:125933 )

• 149+/-12 mmHg compared to 108+/-9 mmHg in wild-type mice

• however, blood pressure is not significantly different from Tg(Alb1-Ren)1Unc containing mice

renal/urinary system

glomerulosclerosis ( J:125933 )

• glomerulosclerosis is worse in male mice than in Tg(Alb1-Ren)1Unc male mice

• however, there is no difference in glomerulosclerosis in female mice compared to Tg(Alb1-Ren)1Unc female mice

renal cast ( J:125933 )

• presence of proteinacious casts is worse in male mice than in Tg(Alb1-Ren)1Unc male mice

• however, there is no difference in presence of proteinacious casts in female mice compared to Tg(Alb1-Ren)1Unc female mice

renal fibrosis ( J:125933 )

• renal fibrosis is worse in male mice than in Tg(Alb1-Ren)1Unc male mice

• however, there is no difference in renal fibrosis in female mice compared to Tg(Alb1-Ren)1Unc female mice

muscle

increased myocardial fiber size ( J:125933 )

• male cardiomyocytes are larger than in Tg(Alb1-Ren)1Unc male mice

• however, there is no difference in cardiomyocyte size in female mice compared to Tg(Alb1-Ren)1Unc female mice

growth/size/body

cardiac hypertrophy ( J:125933 )

• male mice exhibit increased cardiac hypertrophy compared to Tg(Alb1-Ren)1Unc male mice

• however, female mice are not significantly different in terms of cardiac hypertrophy compared to female mice containing Tg(Alb1-Ren)1Unc and the degree of coronary artery fibrosis is the same as in Tg(Alb1-Ren)1Unc mice regardless of gender