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Phenotypes Associated with This Genotype
Genotype
MGI:3763455
Allelic
Composition
Hcrttm1Ywa/Hcrttm1Ywa
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hcrttm1Ywa mutation (2 available); any Hcrt mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• sudden sustained changes in posture which end when activity resumes
• 8-27 episodes in a 4 hour period averaging about 66 seconds in length
• side to side rocking motion in about 75% of behavior arrest episodes (J:57124)
• less affected by intruders (J:85405)
• burrowing and climbing activity frequently precede posture change
• frequent periods of behavioral arrest at night when mice are most active
• sudden collapse of head and neck and body falls to the cage floor
• episodes more frequent and begin earlier when mice are housed in groups
• often preceded by chasing, tail biting and social grooming
• dark phase activity significantly reduced
• ataxic gait appears 1-3 sec before episodes of behavior arrest in about 27% of cases
• shortened REM sleep latency during light phase
• increased time and duration of REM sleep during dark phase
• decreased time between REM episodes
• increased non REM sleep time
• decreased awake time and shorter duration of awake episodes

cardiovascular system
• ephemeral increase at low doses
• less effect of intruders
• less affected by intruders
• less affected by hexamethonium and prazosin
• significantly reduced
• bicucullin stimulation ineffective at very low doses and of shorter duration at higher dose

respiratory system
• respiratory frequency is significantly increased

nervous system
• effect of bicucullin on EEG is of short duration even at higher doses

growth/size/body
• female but not male mice over 100 days in age have significant increases in body weight compared to littermate controls


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory