Phenotypes Associated with This Genotype

Genotype
MGI:3763283

• Allelic Composition: Rbpj^tm1Hon/Rbpj^tm1Hon; Tg(Itgax-cre)1-1Reiz/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased dendritic cell number ( J:125869 )

• splenic dendritic cell (DC) population is decreased similarly to bone marrow deletion of Rbpj; ratio of CD8^-/CD8⁺ dendritic cells is significantly decreased, resulting from 3-fold decrease in numbers of CD8^- DCs with normal numbers of CD8⁺ DCs

• frequency of cytokine-secreting CD8^- DCs in cultured splenocytes is decreased 3-fold compared to controls whereas cytokine-secreting CD8⁺ DCs is unchanged

immune system

decreased dendritic cell number ( J:125869 )

• splenic dendritic cell (DC) population is decreased similarly to bone marrow deletion of Rbpj; ratio of CD8^-/CD8⁺ dendritic cells is significantly decreased, resulting from 3-fold decrease in numbers of CD8^- DCs with normal numbers of CD8⁺ DCs

• frequency of cytokine-secreting CD8^- DCs in cultured splenocytes is decreased 3-fold compared to controls whereas cytokine-secreting CD8⁺ DCs is unchanged

abnormal cytokine secretion ( J:125869 )

• in response to TLR activation, dendritic cell cytokine production is decreased compared to controls