Phenotypes Associated with This Genotype

Genotype
MGI:3762636

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Soat2^tm1Far/Soat2^tm1Far
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased susceptibility to atherosclerosis ( J:81836 )

• near absence of atherosclerotic lesions after 27 weeks on a CHOW diet

• near absence of atherosclerotic lesions after 9 weeks on a Western diet

homeostasis/metabolism

increased circulating HDL cholesterol level ( J:81836 )

• 58% increase in serum HDL cholesterol levels compared to Apoe^tm1Unc/Apoe^tm1Unc control mice

decreased circulating cholesterol level ( J:81836 )

• 60% reduction in total serum cholesterol compared to Apoe^tm1Unc/Apoe^tm1Unc control mice, primarily due to a reduction in plasma cholesterol esters

• plasma free cholesterol is reduced by 18% compared to Apoe^tm1Unc/Apoe^tm1Unc control mice

increased circulating triglyceride level ( J:81836 )

• 90% increase in total serum triglycerides compared to Apoe^tm1Unc/Apoe^tm1Unc control mice

increased phosphatidylcholine-sterol O-acyltransferase activity ( J:81836 )

• increase in the activity of the major enzyme responsible for synthesizing cholesterol esters in the plasma, lecithin/cholesterol acyltransferase