Phenotypes Associated with This Genotype

Genotype
MGI:3762632

• Allelic Composition: Tg(TcraTcrb)425Cbn/?
• Genetic Background: involves: BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal positive T cell selection ( J:87876 )

• positive selection of CD4+ T cells is significantly greater in the thymus and lymph nodes compared to non-transgenic contro

increased CD4-positive, alpha-beta T cell number ( J:87876 )

• cells from thymus and lymph nodes exhibit a fourfold increase in CD4 to CD8 peripheral T cell ratios as compared to non-transgenic control

hematopoietic system

abnormal positive T cell selection ( J:87876 )

• positive selection of CD4+ T cells is significantly greater in the thymus and lymph nodes compared to non-transgenic contro

increased CD4-positive, alpha-beta T cell number ( J:87876 )

• cells from thymus and lymph nodes exhibit a fourfold increase in CD4 to CD8 peripheral T cell ratios as compared to non-transgenic control