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Phenotypes Associated with This Genotype
Genotype
MGI:3762534
Allelic
Composition		 Trp53tm1Holl/Trp53tm1Holl
Genetic
Background		 involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm1Holl mutation (3 available); any Trp53 mutation (238 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
cellular phenotype ( J:68918 )
N
• unlike in p53 null mice, p53 localization to UV irradiation and gamma-radiation induced apoptosis are normal

neoplasm
neoplasm ( J:68918 )
N
• unlike in p53 null mice, no tumors develop by 8 months of age

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/31/2026
MGI 6.24 		The Jackson Laboratory