Analysis Tools
mortality/aging
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• most of the severely growth retarded animals die within 2 weeks of birth
(J:92363)
• 40% to 50% of mice die shortly after birth
(J:131874)
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renal/urinary system
| N |
• mice have normal kidney size at birth
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• mice exhibit increased apoptosis in the kidney, specifically in the cortical interstitium and microcystic tubules, compared to in wild-type mice
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• increased apoptosis in the microcystic renal tubules
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• tubules exhibit microcystic changes such as thin epithelial cells and the lumina is widened compared to in wild-type mice
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digestive/alimentary system
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• ileocecal sphincter at junction between large and small bowel is absent, resulting in continuous transition from lower ileum to colon
• at this transition point, smooth muscle layer is thin and disorganized compared to controls
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• there are signs of aberrant cell differentiation in pyloric region of stomach with ectopic islands of alkaline phosphatase-positive cells located in epithelium
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growth/size/body
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• after first week postnatal, pups show growth retardation with ~1/3 reaching less than 50% of normal bodyweight
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muscle
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• ileocecal sphincter is absent
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cellular
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• mice exhibit increased apoptosis in the kidney, specifically in the cortical interstitium and microcystic tubules, compared to in wild-type mice
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• increased apoptosis in the microcystic renal tubules
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