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Phenotypes Associated with This Genotype
Genotype
MGI:3762258
Allelic
Composition
Ccl19tm1Cys/Ccl19tm1Cys
Genetic
Background
B6.129X1-Ccl19tm1Cys
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccl19tm1Cys mutation (1 available); any Ccl19 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• despite lowered T cell numbers, mice exhibit normal short-term migration of naive T lymphocytes
• mice have fewer CD4+ and CD8+ T cells
• however, mice exhibit normal B cell numbers
• mice exhibit a 30% reduction in T cells that is not thymus-dependent and likely due to a decrease in T cell survival

hematopoietic system
• mice have fewer CD4+ and CD8+ T cells
• however, mice exhibit normal B cell numbers
• mice exhibit a 30% reduction in T cells that is not thymus-dependent and likely due to a decrease in T cell survival


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory