Phenotypes Associated with This Genotype

Genotype
MGI:3762138

• Allelic Composition: Madd^tm1Ytk/Madd^tm1Ytk
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal synaptic vesicle morphology ( J:126302 )

• synaptic vesicle diameter of hippocampal neurons is reduced (40.7+/-0.8 nm compared to 50.8+/-0.7 nm in wild-type mice)

abnormal excitatory postsynaptic currents ( J:126302 )

• mice exhibit a reduced excitatory postsynaptic current (EPSC; 1135+/-1925 pA compared to 5111+/-596 pA in wild-type mice)

• the paired pulse modulation ratio is increased (1.53+/-0.08% compared to 0.96+/-0.02% in wild-type mice)

• increased extracellular calcium levels did not reduce the paired pulse modulation ratio as much as in wild-type mice

• mice exhibit a time-dependent change in the evoked EPSC amplitude from wild-type mice

biphasic excitatory postsynaptic current amplitude ( J:126302 )

• unlike in wild-type mice, the amplitude of evoked EPSC displays a biphasic profile with a peak before the declining phase and a steady-state phase

• however, the rising time EPSC is normal

abnormal miniature excitatory postsynaptic currents ( J:126302 )

• while the mean quantal size of miniature excitatory postsynaptic currents is similar to that in wild-type mice, the frequency of events is reduced (18.3+/-2.5 Hz compared to 34.3+/-4.4 Hz in wild-type mice)