Analysis Tools
immune system
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• unlike in wild-type mice, Langerhans cells in the epidermis are absent
• however, Langerhans cells are present in secondary lymph nodes and the thymus
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• after priming with hapten applied to shaved skin and rechallenge with hapten, mice exhibit a 2-fold increase in ear swelling compared to similarly treated wild-type mice that persists even 3 days after treatment with haptens 2,4-dinitro-1-fluorobenzene or oxazalone
• however, inflammatory response to sodium dodecyl sulfate or benzalkonium chloride is normal as is ovalbumin-induced T cell proliferation
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hematopoietic system
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• unlike in wild-type mice, Langerhans cells in the epidermis are absent
• however, Langerhans cells are present in secondary lymph nodes and the thymus
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