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Phenotypes Associated with This Genotype
Genotype
MGI:3762047
Allelic
Composition
Il36rntm1Hblu/Il36rn+
Tg(KRT14-Il1f6)1Hblu/?
Genetic
Background
involves: 129 * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il36rntm1Hblu mutation (0 available); any Il36rn mutation (22 available)
Tg(KRT14-Il1f6)1Hblu mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• mice exhibit a dilation of superficial dermal blood vessels

immune system
• mice exhibit a mixed dermal inflammatory infiltrate containing predominantly neutrophils and macrophages with fewer lymphocytes and rare eosinophils

integument
• mice exhibit a mixed dermal inflammatory infiltrate containing predominantly neutrophils and macrophages with fewer lymphocytes and rare eosinophils
• mice exhibit intracorneal and intraepithelial pustules, parakerototic and orthokeratotic hyperkeratinosis, dilated superficial dermal blood vessels, and a mixed dermal inflammatory infiltrate
• mice exhibit orthokeratotic hyperkeratinosis
• mice exhibit parakeratotic hyperkeratinosis
• mice have regions of thick and scaly skin
• mice have regions of thick and scaly skin


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory