Analysis Tools
mortality/aging
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• only 1 mouse was found at weaning and 13 dead mice were recovered prior to weaning with milk in their stomachs but small and dehydrated
• however, treatment with 50 ug M616 at P1, 3 and 5 rescues lethality
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cardiovascular system
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• mice exhibit a dilation of superficial dermal blood vessels
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growth/size/body
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• mice that die during the postnatal period have a dehydrated appearance
• however, skin barrier function at E18.5 and P3 is normal
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• mice are smaller than wild-type mice
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immune system
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• mice exhibit a mixed dermal inflammatory infiltrate containing predominantly neutrophils and macrophages with fewer lymphocytes and rare eosinophils
• while treatment with 50 ug M616 at P1, 3 and 5 rescues lethality mice develop severe lesions on their face, neck and ears by 4 to 6 weeks when the treatment is withdrawn
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integument
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• mice exhibit a mixed dermal inflammatory infiltrate containing predominantly neutrophils and macrophages with fewer lymphocytes and rare eosinophils
• while treatment with 50 ug M616 at P1, 3 and 5 rescues lethality mice develop severe lesions on their face, neck and ears by 4 to 6 weeks when the treatment is withdrawn
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• mice exhibit intracorneal and intraepithelial pustules, nucleated corneocytes, parakerototic and orthokeratotic hyperkeratinosis, dilated superficial dermal blood vessels, and a mixed dermal inflammatory infiltrate
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• mice exhibit orthokeratotic hyperkeratinosis
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• mice exhibit parakerototic hyperkeratinosis
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blistering
(
J:126327
)
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• at P3 mice develop an abnormal skin phenotype resembling blistering
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