Phenotypes Associated with This Genotype

Genotype
MGI:3762036

• Allelic Composition: Tg(KRT14-Il1f6)1Hblu/?
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

abnormal tail morphology ( J:126327 )

• mice develop ringtail

growth/size/body

decreased body size ( J:126327 )

• mice are small

immune system

abnormal chemokine level ( J:126327 )

• mice produce elevated levels of GM-CSF (granulocyte monocyte colony stimulating factor), MIP-2 (macrophage-inflammatory protein-2), GCP-2 (granulocyte chemotactic protein) and MCP-3 (monocyte chemotactic protein-3)

skin inflammation ( J:126327 )

• mice develop skin inflammation with infiltrate composed of neutrophils, macrophages and lymphocytes

• mice exhibit increased immunoreactivity for markers of keratinocyte hyperproliferation, macrophages, epidermal Langerhans and dermal dendritic cells, inflammation, and T lymphocytes

• peak inflammatory response occurs at P7 and resolves by P21

• however, immune infiltrate can be reduced by treatment with anti-TNF-alpha or anti-Gr1 antibodies

• while treatment with anti-Gr1 antibodies reduced the number of infiltrating neutrophils it does not eliminate them mice exhibit an increase in CD3+ T lymphocytes in the skin compared to wild-type mice

homeostasis/metabolism

abnormal chemokine level ( J:126327 )

• mice produce elevated levels of GM-CSF (granulocyte monocyte colony stimulating factor), MIP-2 (macrophage-inflammatory protein-2), GCP-2 (granulocyte chemotactic protein) and MCP-3 (monocyte chemotactic protein-3)

integument

skin inflammation ( J:126327 )

• mice develop skin inflammation with infiltrate composed of neutrophils, macrophages and lymphocytes

• mice exhibit increased immunoreactivity for markers of keratinocyte hyperproliferation, macrophages, epidermal Langerhans and dermal dendritic cells, inflammation, and T lymphocytes

• peak inflammatory response occurs at P7 and resolves by P21

• however, immune infiltrate can be reduced by treatment with anti-TNF-alpha or anti-Gr1 antibodies

• while treatment with anti-Gr1 antibodies reduced the number of infiltrating neutrophils it does not eliminate them mice exhibit an increase in CD3+ T lymphocytes in the skin compared to wild-type mice

hyperkeratosis ( J:126327 )

acanthosis ( J:126327 )

thick epidermis ( J:126327 )

• while wild-type mice epidermis decreases in thickness between P1 and P21, mice exhibit increased epidermal thickness with the maximal difference at P5

• however, epidermal thickness can be reduced by treatment with anti-TNF-alpha antibodies

flaky skin ( J:126327 )

skin lesions ( J:126327 )

• recurrence of skin lesions on the face, snout and ears develops at 6 month of age