Phenotypes Associated with This Genotype

Genotype
MGI:3762034

• Allelic Composition: Tg(H2-K-TcrbP14)128Mak/?
• Genetic Background: involves: C57BL/6 * C57L * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell differentiation ( J:111265 )

• majority of T cells in the thymus express a Vbeta8.1 chain

abnormal CD8-positive, alpha-beta T cell differentiation ( J:111265 )

• transgene expression favors selection of CD8 T cells almost 3 times greater than in wild-type mice

• increased selection of CD8 T cells is independent of MHC or Mtv7 alleles

abnormal T cell clonal deletion ( J:111265 )

• in mice expressing the Mtv7^b (Mls^b) allele, the majority of T cells fail to mature due to strong interactions between the transgenic TCR and the Mtv7 allele

increased CD8-positive, alpha-beta T cell number ( J:111265 )

• skewing of the CD4/CD8 ratio from WT (1.2) to transgenic (0.6) is observed in lymph nodes

• skewing of ratio is also observed in the thymus

hematopoietic system

abnormal T cell differentiation ( J:111265 )

• majority of T cells in the thymus express a Vbeta8.1 chain

abnormal CD8-positive, alpha-beta T cell differentiation ( J:111265 )

• transgene expression favors selection of CD8 T cells almost 3 times greater than in wild-type mice

• increased selection of CD8 T cells is independent of MHC or Mtv7 alleles

abnormal T cell clonal deletion ( J:111265 )

• in mice expressing the Mtv7^b (Mls^b) allele, the majority of T cells fail to mature due to strong interactions between the transgenic TCR and the Mtv7 allele

increased CD8-positive, alpha-beta T cell number ( J:111265 )

• skewing of the CD4/CD8 ratio from WT (1.2) to transgenic (0.6) is observed in lymph nodes

• skewing of ratio is also observed in the thymus