Phenotypes Associated with This Genotype

Genotype
MGI:3761723

• Allelic Composition: Pcna^tm1Jcbs/Pcna^tm1Jcbs
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:125916 )

• homozygous pups only make up 5% of litters instead of the expected 25%

reproductive system

absent germ cells ( J:125916 )

• complete lack of germ cells in the testes or ovaries

infertility ( J:125916 )

• both female and male mice are infertile

immune system

abnormal somatic hypermutation frequency ( J:125916 )

• 10 fold reduction of transitions and transversions of template A/T

• compensatory increase of mutations on template G/C

hematopoietic system

abnormal somatic hypermutation frequency ( J:125916 )

• 10 fold reduction of transitions and transversions of template A/T

• compensatory increase of mutations on template G/C

cellular

absent germ cells ( J:125916 )

• complete lack of germ cells in the testes or ovaries