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Phenotypes Associated with This Genotype
Genotype
MGI:3761679
Allelic
Composition
B9d2/Tgfb1tm1Flv/B9d2/Tgfb1tm1Flv
Tg(CD207-cre)1Dhka/?
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B9d2/Tgfb1tm1Flv mutation (0 available); any Tgfb1 mutation (34 available)
Tg(CD207-cre)1Dhka mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• although the number of Langerhans cells is substantially reduced compared to in wild-type mice, a variable number of Langerhans cells are present in the epidermis (0.02% to 0.1% of total epidermal cells compared to 0.42% to 1.17% in wild-type mice)
• Langerhans cells are absent from the vast majority of the ear with Langerhans cells being found at the edge of the ear in clusters

hematopoietic system
• although the number of Langerhans cells is substantially reduced compared to in wild-type mice, a variable number of Langerhans cells are present in the epidermis (0.02% to 0.1% of total epidermal cells compared to 0.42% to 1.17% in wild-type mice)
• Langerhans cells are absent from the vast majority of the ear with Langerhans cells being found at the edge of the ear in clusters


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/28/2026
MGI 6.24
The Jackson Laboratory