Phenotypes Associated with This Genotype

Genotype
MGI:3761678

• Allelic Composition: Tgfbr2^tm1.2Hlm/Tgfbr2^tm1.2Hlm; Tg(CD207-cre)1Dhka/?
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * SJL/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased Langerhans cell number ( J:126147 )

• although the number of Langerhans cells is substantially reduced compared to in wild-type mice, a variable number of Langerhans cells are present in the epidermis (0.02% to 0.59% of total epidermal cells compared to 0.46% to 0.89% in wild-type mice)

• the ratio of Langerhans cells in the epidermis increases with age

hematopoietic system

decreased Langerhans cell number ( J:126147 )

• although the number of Langerhans cells is substantially reduced compared to in wild-type mice, a variable number of Langerhans cells are present in the epidermis (0.02% to 0.59% of total epidermal cells compared to 0.46% to 0.89% in wild-type mice)

• the ratio of Langerhans cells in the epidermis increases with age