Phenotypes Associated with This Genotype

Genotype
MGI:3761388

• Allelic Composition: Tg(CD2-Myb/en)2Kmw/Tg(CD2-Myb/en)2Kmw
• Genetic Background: involves: C57BL/10 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:126456 )

• mice die prior to 6 months of age from disseminated infections

immune system

decreased T cell proliferation ( J:126456 )

• T cells are almost completely unresponsive to AC11- and PHA-induced proliferation

small thymus ( J:126456 )

• mice have little or no thymus

increased double-negative T cell number ( J:126456 )

• the percent of double negative cells is increased

• the percent of CD3- and CD3^low double negative cells is increased especially in homozygotes

decreased T cell number ( J:126456 )

• T cell number is reduced by 20-fold

decreased double-positive T cell number ( J:126456 )

• double positive cells only comprise 35% of the population compared to 70% to 80% in wild-type mice

small spleen ( J:126456 )

• mice have spleens that are between a half to a quarter the size of those in wild-type mice

growth/size/body

decreased body size ( J:126456 )

• mice are runted

hematopoietic system

decreased T cell proliferation ( J:126456 )

• T cells are almost completely unresponsive to AC11- and PHA-induced proliferation

small thymus ( J:126456 )

• mice have little or no thymus

increased double-negative T cell number ( J:126456 )

• the percent of double negative cells is increased

• the percent of CD3- and CD3^low double negative cells is increased especially in homozygotes

decreased T cell number ( J:126456 )

• T cell number is reduced by 20-fold

decreased double-positive T cell number ( J:126456 )

• double positive cells only comprise 35% of the population compared to 70% to 80% in wild-type mice

small spleen ( J:126456 )

• mice have spleens that are between a half to a quarter the size of those in wild-type mice

endocrine/exocrine glands

small thymus ( J:126456 )

• mice have little or no thymus

cellular

decreased T cell proliferation ( J:126456 )

• T cells are almost completely unresponsive to AC11- and PHA-induced proliferation