Phenotypes Associated with This Genotype

Genotype
MGI:3761387

• Allelic Composition: Tg(CD2-Myb/en)2Kmw/?
• Genetic Background: involves: C57BL/10 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased T cell proliferation ( J:126456 )

• T cell proliferation induced by 2C11 is reduced by 50%

• T cell proliferation induced by PHA is reduced to 68% of wild-type mice

increased double-negative T cell number ( J:126456 )

• the percent of CD3- and CD3^low double negative cells is increased especially in homozygotes

decreased T cell number ( J:126456 )

• T cell number is reduced by 2- to 4-fold

abnormal single-positive T cell number ( J:126456 )

• mice exhibit a reduction in the ratio of CD4+ to CD8+ single positive cells compared to wild-type mice

• however, the number of double positive cells is unaffected

hematopoietic system

decreased T cell proliferation ( J:126456 )

• T cell proliferation induced by 2C11 is reduced by 50%

• T cell proliferation induced by PHA is reduced to 68% of wild-type mice

increased double-negative T cell number ( J:126456 )

• the percent of CD3- and CD3^low double negative cells is increased especially in homozygotes

decreased T cell number ( J:126456 )

• T cell number is reduced by 2- to 4-fold

abnormal single-positive T cell number ( J:126456 )

• mice exhibit a reduction in the ratio of CD4+ to CD8+ single positive cells compared to wild-type mice

• however, the number of double positive cells is unaffected

cellular

decreased T cell proliferation ( J:126456 )

• T cell proliferation induced by 2C11 is reduced by 50%

• T cell proliferation induced by PHA is reduced to 68% of wild-type mice