Phenotypes Associated with This Genotype

Genotype
MGI:3761386

• Allelic Composition: Lrfn2^{Tg(CD2-Myb/en)5Kmw}/Lrfn2^{Tg(CD2-Myb/en)5Kmw}
• Genetic Background: involves: C57BL/10 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased T cell proliferation ( J:126456 )

• T cells are almost completely unresponsive to AC11- and PHA-induced proliferation

abnormal thymus cortex morphology ( J:126456 )

• thymi display structurally abnormal cortices

abnormal thymus medulla morphology ( J:126456 )

• thymi lack discernible medullas

small thymus ( J:126456 )

• mice have little or no thymus

decreased T cell number ( J:126456 )

• T cell number is reduced by 20-fold

decreased double-negative T cell number ( J:126456 )

• CD4-CD8- double negative cells are decreased by 62% of levels in Tg(CD2-Myb/en)2Kmw homozygotes

decreased CD8-positive, alpha-beta T cell number ( J:126456 )

• the number of CD8+ single negative by 4-fold compared to in wild-type mice

small spleen ( J:126456 )

• mice have spleens that are between a half to a quarter the size of those in wild-type mice

• mice have little or no thymus

hematopoietic system

decreased T cell proliferation ( J:126456 )

• T cells are almost completely unresponsive to AC11- and PHA-induced proliferation

abnormal thymus cortex morphology ( J:126456 )

• thymi display structurally abnormal cortices

abnormal thymus medulla morphology ( J:126456 )

• thymi lack discernible medullas

small thymus ( J:126456 )

• mice have little or no thymus

decreased T cell number ( J:126456 )

• T cell number is reduced by 20-fold

decreased double-negative T cell number ( J:126456 )

• CD4-CD8- double negative cells are decreased by 62% of levels in Tg(CD2-Myb/en)2Kmw homozygotes

decreased CD8-positive, alpha-beta T cell number ( J:126456 )

• the number of CD8+ single negative by 4-fold compared to in wild-type mice

small spleen ( J:126456 )

• mice have spleens that are between a half to a quarter the size of those in wild-type mice

• mice have little or no thymus

endocrine/exocrine glands

abnormal thymus cortex morphology ( J:126456 )

• thymi display structurally abnormal cortices

abnormal thymus medulla morphology ( J:126456 )

• thymi lack discernible medullas

small thymus ( J:126456 )

• mice have little or no thymus

cellular

decreased T cell proliferation ( J:126456 )

• T cells are almost completely unresponsive to AC11- and PHA-induced proliferation