Phenotypes Associated with This Genotype

Genotype
MGI:3761385

• Allelic Composition: Lrfn2^{Tg(CD2-Myb/en)5Kmw}/Lrfn2⁺
• Genetic Background: involves: C57BL/10 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased T cell proliferation ( J:126456 )

• T cell proliferation induced by 2C11 is reduced by 50%

abnormal bone marrow cell morphology/development ( J:125805 )

• mice exhibit a slight increase in proerythroblasts and basophilic erythroblasts compared to Tg(H2-K-Myc)1Brn Lrfn2^{Tg(CD2-Myb/en)5Kmw} mice

abnormal common myeloid progenitor cell morphology ( J:125805 )

• in a 14 day culture, spleen cells produce 2.5-fold more derived spleen-derived colonies

• the proportion of colony-forming unit-granulocyte, erythrocyte, monocyte (CFU-GEMM) from cultured spleen cells is increased to 19% compared to 10% for wild-type spleen cells

• in a 14 day culture, bone marrow cells colony-forming unit-granulocyte, erythrocyte, monocyte (CFU-GEMM) and erythroid burst colonies

decreased T cell number ( J:126456 )

• T cell number is reduced by 2- to 4-fold

immune system

decreased T cell proliferation ( J:126456 )

• T cell proliferation induced by 2C11 is reduced by 50%

decreased T cell number ( J:126456 )

• T cell number is reduced by 2- to 4-fold

abnormal lymph node morphology ( J:125805 )

• lymph nodes contain many nonlymphoid cells that are a mixture of late-stage erythroblasts, reticulocytes and mature erythrocytes although to a lesser degree than in homozygotes mice exhibit more mature R4 and R5 gate cells than in Tg(H2-K-Myc)1Brn Lrfn2^{Tg(CD2-Myb/en)5Kmw} mice

cellular

decreased T cell proliferation ( J:126456 )

• T cell proliferation induced by 2C11 is reduced by 50%