Analysis Tools
mortality/aging
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• remaining mice die soon after birth
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• 40% of mice die prior to E11.5 of unknown causes
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reproductive system
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• ovaries and testies are present and morphologically normal
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• seminal vesicles are absent
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absent uterus
(
J:76368
)
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• the normal architecture of the epididymis is lost
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embryo
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• at E13.5, the Mullerian duct is blind-ending
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• in 18 embryos lacking metanephric kidney induction, the Wolffian duct is blind-ending
• at E10.5, the basement membranes of the elongating Wolffian duct is discontinuous whereas it is continuous in wild-type mice
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renal/urinary system
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• frequently the Bowmann's capsule is partially or completely filled with red blood cells
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kidney cyst
(
J:76368
)
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• only male mice exhibit cystic enlargements
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• frequently the Bowmann's capsule is partially or completely filled with red blood cells
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• mice that possess kidneys exhibit 30% less mature glomeruli than wild-type mice; of these 60% develop normally while the rest show either a reduced (25%) or missing (15%) capillary tuft
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• mice that possess kidneys exhibit 30% less mature glomeruli than wild-type mice
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• at E13.5, mice possess fewer tubuli than wild-type mice
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• at E13.5, the metanephroi are absent
• however, the metanephric blastema is present
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• three male mice with kidneys exhibit hydronephric kidneys with a thinned parenchyma and the ureter connects aberrantly to the vas deferens or in one case the epididymys
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absent kidney
(
J:76368
)
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• at E18.5, 80% of mice lack both kidneys
• however, adrenal glands are present and morphologically normal
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single kidney
(
J:76368
)
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• at E18.5, 10% of mice lack one kidney
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• three male mice with kidneys exhibit hydronephric kidneys with a thinned parenchyma and the ureter connects aberrantly to the vas deferens or in one case the epididymis
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• at E11, in most embryos the ureteric buds are absent
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• at E18.8, kidneys that are present in 10% of mice are non-functional
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respiratory system
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• at E18.5, prealveolar sacculi are immature and only poorly inflated
• at E18.5, only 10% of prealveolar sacculi form
• however, at E11.5 and E13.5 lung development is normal and by E18.5 surfactant protein C is detected
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• at E18.5, mesenchymal thickening between the terminal airspaces is observed
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small lung
(
J:76368
)
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• at E18.5, lung size is smaller and more compact than in wild-type mice
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• at E18.5, the major bronchial trees are more compact and smaller than in wild-type mice
• however, at E13.5 and E15.5 lung development is normal and by E18.5 surfactant protein C is detected
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growth/size/body
kidney cyst
(
J:76368
)
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• only male mice exhibit cystic enlargements
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• at E18.5, mice are 20% smaller than wild-type mice
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endocrine/exocrine glands
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• seminal vesicles are absent
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cardiovascular system
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• frequently the Bowmann's capsule is partially or completely filled with red blood cells
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cellular
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• only 30% of mice exhibit normal basement membranes, in 30% only amorphously deposited material is detected, and in the remaining mice the basement membrane is completely missing and epithelial cell protrusions enter into the empty space
• at E10.5, the basement membranes of the elongating Wolffian duct is discontinuous whereas it is continuous in wild-type mice
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