Phenotypes Associated with This Genotype

Genotype
MGI:3761145

• Allelic Composition: Ramp1^tm1.1Tsuj/Ramp1^tm1.1Tsuj
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased systemic arterial systolic blood pressure ( J:125974 )

• mice exhibit 40% higher blood pressure compared to wild-type littermates

• blood pressure increases slightly with age

decreased vasodilation ( J:125974 )

• blood pressure is refractory to administration of some vasodilators (alpha calcitonin gene-related peptide, adrenomedullin)

• relaxation of aortic rings by vasodilators is reduced in ex vivo assays

muscle

decreased vasodilation ( J:125974 )

• blood pressure is refractory to administration of some vasodilators (alpha calcitonin gene-related peptide, adrenomedullin)

• relaxation of aortic rings by vasodilators is reduced in ex vivo assays