Phenotypes Associated with This Genotype

Genotype
MGI:3761003

• Allelic Composition: Bdnf^tm1Jae/Bdnf^tm1Jae; Ntf5^tm1Jae/Ntf5^tm1Jae
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:25566 )

• most homozygous mice die within 48 hours of birth, with only a few surviving up to 10 days of age

growth/size/body

postnatal growth retardation ( J:25566 )

• homozygous mice are the same size as controls at birth, but fail to grow thereafter

nervous system

decreased sensory neuron number ( J:25566 )

• significant loss of all sensory neuron types in the trigeminal, vestibular, nodose-petrosal and geniculate ganglia in homozygous mice

• no statistical difference in the number of facial motor neurons is seen compared to controls

small geniculate ganglion ( J:25566 )

• approximately 95% of the neurons are lost from the geniculate ganglion at E18.5

small petrosal ganglion ( J:25566 )

• approximately 90% of the neurons are lost from the nodose-petrosal ganglion at E18.5

small trigeminal ganglion ( J:25566 )

• approximately 30% of the neurons are lost from the trigeminal ganglion at E18.5

small nodose ganglion ( J:25566 )

• approximately 90% of the neurons are lost from the nodose-petrosal ganglion at E18.5

small vestibular ganglion ( J:25566 )

• approximately 80% of the neurons are lost from the vestibular ganglion at E18.5

abnormal trigeminal nerve morphology ( J:123022 )

• mice exhibit a 25% loss of trigeminal neurons at birth

behavior/neurological

impaired balance ( J:25566 )

impaired coordination ( J:25566 )