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Phenotypes Associated with This Genotype
Genotype
MGI:3760860
Allelic
Composition		 Tg(TcraTcrb)425Cbn/0
Genetic
Background		 involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(TcraTcrb)425Cbn mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal positive T cell selection ( J:125548 )
• positive selection of CD4+ T cells is significantly greater in the thymus compared to Tg(Tcra51-11.5,Tcrb51-11.5)AR206Ayr mice

immune system
abnormal positive T cell selection ( J:125548 )
• positive selection of CD4+ T cells is significantly greater in the thymus compared to Tg(Tcra51-11.5,Tcrb51-11.5)AR206Ayr mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory