Phenotypes Associated with This Genotype

Genotype
MGI:3760855

• Allelic Composition: Cd79a^tm5.1Cgn/Cd79a^tm5.1Cgn; Igh^tm1.2Rsky/Igh^tm1.2Rsky
• Genetic Background: involves: 129 * BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased T cell number ( J:125719 )

• 2 fold decrease in the number of T cells in the spleen

abnormal B cell morphology ( J:125719 )

abnormal class switch recombination ( J:125719 )

• more than a five fold increase in the percentage of B cells expressing IgG1

decreased immature B cell number ( J:125719 )

• less than 1 percent of bone marrow cells are immature B cells ( normal is about 8%)

increased pro-B cell number ( J:125719 )

• about 2 fold increase due to block in development from pro-B cell to pre-B cell

decreased mature B cell number ( J:125719 )

• 10 fold decrease in the number of B cells in the spleen

• 6 fold decrease in the number of B cells in the peritoneal cavity

• these numbers are higher than mice that are only null for Igalpha expression

increased B-1b cell number ( J:125719 )

• increased both in the spleen and peritoneal cavity

decreased pre-B cell number ( J:125719 )

• very few pre-B cells exist in the bone marrow

hematopoietic system

decreased T cell number ( J:125719 )

• 2 fold decrease in the number of T cells in the spleen

abnormal B cell morphology ( J:125719 )

abnormal class switch recombination ( J:125719 )

• more than a five fold increase in the percentage of B cells expressing IgG1

decreased immature B cell number ( J:125719 )

• less than 1 percent of bone marrow cells are immature B cells ( normal is about 8%)

increased pro-B cell number ( J:125719 )

• about 2 fold increase due to block in development from pro-B cell to pre-B cell

decreased mature B cell number ( J:125719 )

• 10 fold decrease in the number of B cells in the spleen

• 6 fold decrease in the number of B cells in the peritoneal cavity

• these numbers are higher than mice that are only null for Igalpha expression

increased B-1b cell number ( J:125719 )

• increased both in the spleen and peritoneal cavity

decreased pre-B cell number ( J:125719 )

• very few pre-B cells exist in the bone marrow