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Phenotypes Associated with This Genotype
Genotype
MGI:3760847
Allelic
Composition		 Cd22tm1Lam/Cd22tm1Lam
Ightm1.2Rsky/Ightm1.2Rsky
Genetic
Background		 involves: 129 * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd22tm1Lam mutation (1 available); any Cd22 mutation (59 available)
Ightm1.2Rsky mutation (0 available); any Igh mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B-1a cell number ( J:125719 )
• 5 fold reduction in the peritoneum
abnormal B cell activation ( J:125719 )
• enhanced Ca2+ mobilization to high levels upon activation of B cells

hematopoietic system
decreased B-1a cell number ( J:125719 )
• 5 fold reduction in the peritoneum
abnormal B cell activation ( J:125719 )
• enhanced Ca2+ mobilization to high levels upon activation of B cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory