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Phenotypes Associated with This Genotype
Genotype
MGI:3760803
Allelic
Composition		 Runx1tm1Yg/Runx1tm1Yg
Tg(Lck-cre)1Jtak/?
Genetic
Background		 either: (involves: 129/Sv * 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * ICR) or (involves: 129S1/Sv * 129X1/SvJ * MF1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1tm1Yg mutation (2 available); any Runx1 mutation (34 available)
Tg(Lck-cre)1Jtak mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell number ( J:125830 )
• despite normal thymus development and a complete rescue of embryonic lethality, mice display a reduction in the number of Runx1+ T cells

hematopoietic system
decreased T cell number ( J:125830 )
• despite normal thymus development and a complete rescue of embryonic lethality, mice display a reduction in the number of Runx1+ T cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory