Analysis Tools
mortality/aging
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• mice die 2 to 3 days after birth
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immune system
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• at E16.5, the thymus has a scalloped capsular surface of predominantly epithelial cells with no evidence of an organized medulla or cortex
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• at E17.5, the thymus lacks corticomedullary organization
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small thymus
(
J:125830
)
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• at P1.5, the thymus is one third of the size of a normal thymus
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• in embryos and neonates
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• at E14.5, thymocyte numbers are reduced 3-fold compared to in wild-type mice due to increased thymocyte apoptosis
• however, thymocyte proliferation and cell cycle progression is normal
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thymus cyst
(
J:125830
)
|
• at E14.5 and E15.5, thymi contain scattered cysts from accelerated epithelial turnover
• at E17.5, the thymus occasionally contains cysts
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• mice exhibit a 4-fold reduction in T cell precursors compared to wild-type mice
• when E15.5 fetal liver cells are cultured under limiting dilution conditions in fetal thymic organ culture successful repopulation was lower than for wild-type cells
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• mice display an increased proportion of DN3 cells and a corresponding reduction in DN4 cells relative to levels in wild-type mice (DN3 to DN4 ratio 1.51+/-0.31 compared to 0.65+/-0.15 in wild-type mice)
• however, by P3.5 T cell differentiation is recovered to wild-type proportions
|
|
• at E16.5, mice exhibit a 2.5-fold increase in double positive cells compared to wild-type mice
• at E17.5, the decrease in double positive cells is more pronounced and accompanied by an increase in CD4+CD8low cells
• after 16 days in a fetal thymic organ culture, an increased proportion of double positive CD4+CD8low cells and a 2-fold reduction in single positive cells was observed
|
|
• after 16 days in a fetal thymic organ culture, an increased proportion of double positive CD4+CD8low cells and a 2-fold reduction in single positive cells was observed
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growth/size/body
thymus cyst
(
J:125830
)
|
• at E14.5 and E15.5, thymi contain scattered cysts from accelerated epithelial turnover
• at E17.5, the thymus occasionally contains cysts
|
hematopoietic system
|
• at E16.5, the thymus has a scalloped capsular surface of predominantly epithelial cells with no evidence of an organized medulla or cortex
|
|
• at E17.5, the thymus lacks corticomedullary organization
|
small thymus
(
J:125830
)
|
• at P1.5, the thymus is one third of the size of a normal thymus
|
|
• in embryos and neonates
|
|
• at E14.5, thymocyte numbers are reduced 3-fold compared to in wild-type mice due to increased thymocyte apoptosis
• however, thymocyte proliferation and cell cycle progression is normal
|
thymus cyst
(
J:125830
)
|
• at E14.5 and E15.5, thymi contain scattered cysts from accelerated epithelial turnover
• at E17.5, the thymus occasionally contains cysts
|
|
• in vitro colony formation ability by fetal liver cells is reduced compared to that for wild-type cells
• fetal liver cells contain few hematopoietic progenitor cells compared to wild-type fetal liver cells
• at E17.5 and E18.5, mice display fewer Gr-1/CD18+ and CD11a+/CD11b+ cells compared to wild-type mice
• at E17.5 and E18.5, mice exhibit a 2-fold reduction in the proportion of CD44+ to c-Kit+ hematopoietic progenitor cells and an even greater reduction in CD34+ cells compared to wild-type mice
|
|
• mice exhibit a 4-fold reduction in T cell precursors compared to wild-type mice
• when E15.5 fetal liver cells are cultured under limiting dilution conditions in fetal thymic organ culture successful repopulation was lower than for wild-type cells
|
|
• mice display an increased proportion of DN3 cells and a corresponding reduction in DN4 cells relative to levels in wild-type mice (DN3 to DN4 ratio 1.51+/-0.31 compared to 0.65+/-0.15 in wild-type mice)
• however, by P3.5 T cell differentiation is recovered to wild-type proportions
|
|
• at E16.5, mice exhibit a 2.5-fold increase in double positive cells compared to wild-type mice
• at E17.5, the decrease in double positive cells is more pronounced and accompanied by an increase in CD4+CD8low cells
• after 16 days in a fetal thymic organ culture, an increased proportion of double positive CD4+CD8low cells and a 2-fold reduction in single positive cells was observed
|
|
• after 16 days in a fetal thymic organ culture, an increased proportion of double positive CD4+CD8low cells and a 2-fold reduction in single positive cells was observed
|
cellular
endocrine/exocrine glands
|
• at E16.5, the thymus has a scalloped capsular surface of predominantly epithelial cells with no evidence of an organized medulla or cortex
|
|
• at E17.5, the thymus lacks corticomedullary organization
|
small thymus
(
J:125830
)
|
• at P1.5, the thymus is one third of the size of a normal thymus
|
|
• in embryos and neonates
|
|
• at E14.5, thymocyte numbers are reduced 3-fold compared to in wild-type mice due to increased thymocyte apoptosis
• however, thymocyte proliferation and cell cycle progression is normal
|
thymus cyst
(
J:125830
)
|
• at E14.5 and E15.5, thymi contain scattered cysts from accelerated epithelial turnover
• at E17.5, the thymus occasionally contains cysts
|
