Phenotypes Associated with This Genotype

Genotype
MGI:3760790

• Allelic Composition: Kit^Mhdasco5/Kit^Mhdasco5
• Genetic Background: C3HeB/FeJ-Kit^Mhdasco5

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Liver defects in Kit^Mhdasco5/Kit^Mhdasco5 mice during postnatal development

mortality/aging

postnatal lethality, incomplete penetrance ( J:125831 )

• 50% death before 7.5 days of age

• 25% survival to weaning

growth/size/body

slow postnatal weight gain ( J:125831 )

• 50% weight reduction at 21 days after birth

pigmentation

abnormal coat/hair pigmentation ( J:125831 )

• overall white coat color with black eyes

hematopoietic system

macrocytic anemia ( J:125831 )

• at 7.5 days of age

• severe

abnormal erythrocyte morphology ( J:125831 )

decreased erythrocyte cell number ( J:125831 )

• 2.5x10⁶/ul

decreased hematocrit ( J:125831 )

• 21.2%

increased hemoglobin content ( J:125831 )

• 5.9g/dl

increased mean corpuscular volume ( J:125831 )

• 85.9 femptoliters

liver/biliary system

hepatic steatosis ( J:125831 )

• tan or yellowish in color at 7.5 days of age due to steatosis

• detectable by day 2.5

• dramatic increase in triglycerides

• slight decrease in cholesterol

homeostasis/metabolism

decreased circulating cholesterol level ( J:125831 )

• at 2.5 days of age and later

• lower levels of free cholesterol in plasma

decreased circulating HDL cholesterol level ( J:125831 )

decreased circulating LDL cholesterol level ( J:125831 )

reproductive system

reproductive system phenotype ( J:125831 )

N • testis shows a normal appearance and organization and spermatogenesis occurs normally

integument

abnormal coat/hair pigmentation ( J:125831 )

• overall white coat color with black eyes