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Phenotypes Associated with This Genotype
Genotype
MGI:3760790
Allelic
Composition
KitMhdasco5/KitMhdasco5
Genetic
Background
C3HeB/FeJ-KitMhdasco5
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
KitMhdasco5 mutation (1 available); any Kit mutation (96 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Liver defects in KitMhdasco5/KitMhdasco5 mice during postnatal development

mortality/aging
• 50% death before 7.5 days of age
• 25% survival to weaning

growth/size/body
• 50% weight reduction at 21 days after birth

pigmentation
• overall white coat color with black eyes

hematopoietic system
• at 7.5 days of age
• severe
• 85.9 femptoliters

liver/biliary system
• tan or yellowish in color at 7.5 days of age due to steatosis
• detectable by day 2.5
• dramatic increase in triglycerides
• slight decrease in cholesterol

homeostasis/metabolism
• at 2.5 days of age and later
• lower levels of free cholesterol in plasma

reproductive system
N
• testis shows a normal appearance and organization and spermatogenesis occurs normally

integument
• overall white coat color with black eyes


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory