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Phenotypes Associated with This Genotype
Genotype
MGI:3760747
Allelic
Composition		 Tg(Tcra2C,Tcrb2C)1Dlo/?
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tcra2C,Tcrb2C)1Dlo mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal CD8-positive, alpha beta T cell morphology ( J:125259 )
• CD5 levels are reduced, indicating CD8-positive T cells are being activated by self-antigen

hematopoietic system
abnormal CD8-positive, alpha beta T cell morphology ( J:125259 )
• CD5 levels are reduced, indicating CD8-positive T cells are being activated by self-antigen

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory