Phenotypes Associated with This Genotype

Genotype
MGI:3760621

• Allelic Composition: Rapgef6^tm1.1Tkat/Rapgef6^tm1.1Tkat
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

enlarged spleen ( J:126164 )

• mice exhibit enlarged spleen compared to wild-type mice

• however, no defects in spleen histology are observed

cellular

decreased cell adhesion ( J:126164 )

• TNF-alpha-stimulated adhesion in splenocytes is reduced relative to in wild-type cells

• however, PMA-stimulated adhesion in splenocytes and TNF-alpha- and PMA-stimulated adhesion thymocytes are normal LFA-1 mediated adhesion to ICAM-1 in splenocytes but not thymocytes is impaired

hematopoietic system

enlarged spleen ( J:126164 )

• mice exhibit enlarged spleen compared to wild-type mice

• however, no defects in spleen histology are observed

growth/size/body

enlarged spleen ( J:126164 )

• mice exhibit enlarged spleen compared to wild-type mice

• however, no defects in spleen histology are observed