Phenotypes Associated with This Genotype

Genotype
MGI:3760114

• Allelic Composition: Magel2^tm1Stw/Magel2^tm1Stw
• Genetic Background: C57BL/6-Magel2^tm1Stw

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:125637 )

• when the Magel2^tm1Stw allele is inherited paternally, 10% fewer mice survive to weaning than expected

reproductive system

reduced male fertility ( J:125637 )

♂ • when the Magel2^tm1Stw allele is inherited paternally, males reproduce but with decreasing frequency and cease mating by 16 weeks unlike wild-type mice

♂ • however, no defects in spermatogenesis and testes weight are observed

behavior/neurological

decreased compensatory feeding amount ( J:125637 )

• when the Magel2^tm1Stw allele is inherited paternally, after 24 hours starvation mice consume less food than wild-type mice

decreased locomotor activity ( J:125637 )

• when the Magel2^tm1Stw allele is inherited paternally, mice run significantly less than wild-type mice (3047+/-930 counts per day compared to 12770+/-2343 counts per day for wild-type mice)

• when the Magel2^tm1Stw allele is inherited paternally, mice run in more frequent and shorter bouts (8.5+/-0.7 bouts per day compared to 4.9+/-0.4 bouts per day for wild-type mice and 21.8+/-4.3 minutes per bout compared to 83.1+/-15.4 minutes per bout for wild-type mice)

abnormal circadian behavior ( J:125637 )

• when the Magel2^tm1Stw allele is inherited paternally, rhythms have lower chi-squared periodogram amplitudes than in wild-type mice

abnormal locomotor circadian rhythm ( J:125637 )

• when the Magel2^tm1Stw allele is inherited paternally, mice run significantly less than wild-type mice (3047+/-930 counts per day compared to 12770+/-2343 counts per day for wild-type mice)

• when the Magel2^tm1Stw allele is inherited paternally, mice run in more frequent and shorter bouts (8.5+/-0.7 bouts per day compared to 4.9+/-0.4 bouts per day for wild-type mice and 21.8+/-4.3 minutes per bout compared to 83.1+/-15.4 minutes per bout for wild-type mice)

• when the Magel2^tm1Stw allele is inherited paternally, mice exhibit less daily activity during the subjective night (76.9+/-2.8% compared to 86.6+/-2.5% for wild-type mice)when the Magel2^tm1Stw allele is inherited paternally, mice exhibit less daily activity during the subjective night (76.9+/-2.8% compared to 86.6+/-2.5% for wild-type mice)

growth/size/body

growth/size/body region phenotype ( J:125637 )

N • when the Magel2^tm1Stw allele is inherited paternally, surviving mice display no abnormalities in size or weight up to 2 years of age

cellular

maternal imprinting ( J:125637 )

• only the paternally inherited allele is expressed