Phenotypes Associated with This Genotype

Genotype
MGI:3760088

• Allelic Composition: Krt19^tm1Alki/Krt19⁺
• Genetic Background: involves: 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Spermatid and epididymal sperm tail abnormalities in Krt19^tm1Alki/Krt19^tm1Alki and Krt19^tm1Alki/Krt19⁺ mice

reproductive system

abnormal sperm flagellum morphology ( J:125621 )

♂ • 40% of epididymal sperm display normal head shape but tail abnormalities including hook- and U-shaped tails, sperm with shortened and thick tails, and conjoined sperm with hooked-shaped tails fused distally

♂ • however, sperm display forward motility and axial rotation and random active particulate motion is observed in the residual cytoplasm

thick sperm flagellum ( J:125621 )

♂

coiled sperm flagellum ( J:125621 )

♂ • coiled flagella are observed in maturing spermatids and epididymal sperm of mutant mice

short sperm flagellum ( J:125621 )

♂

abnormal spermatid morphology ( J:125621 )

♂

ectopic manchette ( J:125621 )

♂ • 35% of round spermatids display ectopic manchette

cellular

abnormal sperm flagellum morphology ( J:125621 )

♂ • 40% of epididymal sperm display normal head shape but tail abnormalities including hook- and U-shaped tails, sperm with shortened and thick tails, and conjoined sperm with hooked-shaped tails fused distally

♂ • however, sperm display forward motility and axial rotation and random active particulate motion is observed in the residual cytoplasm

thick sperm flagellum ( J:125621 )

♂

coiled sperm flagellum ( J:125621 )

♂ • coiled flagella are observed in maturing spermatids and epididymal sperm of mutant mice

short sperm flagellum ( J:125621 )

♂

abnormal spermatid morphology ( J:125621 )

♂

ectopic manchette ( J:125621 )

♂ • 35% of round spermatids display ectopic manchette