Phenotypes Associated with This Genotype

Genotype
MGI:3760078

• Allelic Composition: Cdk8^{GT(RRS314)Byg}/Cdk8^{GT(RRS314)Byg}
• Genetic Background: involves: 129P2/OlaHsd * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:125327 )

• only 4 embryos are recovered at E2.5 and 1 at E3.0 indicating very early embryonic lethality

• embryos extracted from a superovulated female and grown in culture have a runted appearance and reduced viability at day 0.5

embryo

abnormal preimplantation embryo development ( J:125327 )

failure of morula compaction ( J:125327 )

• blastomeres are fragmented at the 8-cell stage and no embryo compaction is observed